Nanobodies targeting norovirus capsid reveal functional epitopes and potential mechanisms of neutralization.

Koromyslova, Anna D; Hansman, Grant S

Koromyslova, Anna D; Hansman, Grant S.

Affiliation

Koromyslova AD; Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg, Germany.
Hansman GS; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.

PLoS Pathog ; 13(11): e1006636, 2017 Nov.

Article in En | MEDLINE | ID: mdl-29095961

Subject(s)

Antibodies, Neutralizing/pharmacology; Antiviral Agents/pharmacology; Capsid Proteins/antagonists & inhibitors; Capsid/drug effects; Models, Molecular; Norovirus/drug effects; Single-Domain Antibodies/pharmacology; Antibodies, Neutralizing/chemistry; Antibodies, Neutralizing/metabolism; Antibody Affinity; Antiviral Agents/chemistry; Antiviral Agents/metabolism; Binding Sites, Antibody; Binding, Competitive; Blood Group Antigens/chemistry; Blood Group Antigens/metabolism; Capsid/chemistry; Capsid/metabolism; Capsid/ultrastructure; Capsid Proteins/chemistry; Capsid Proteins/metabolism; Cross Reactions; Crystallography, X-Ray; Dynamic Light Scattering; Epitopes; Kinetics; Microscopy, Electron, Transmission; Norovirus/chemistry; Norovirus/metabolism; Norovirus/ultrastructure; Protein Conformation; Protein Interaction Domains and Motifs; Single-Domain Antibodies/chemistry; Single-Domain Antibodies/metabolism; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Models, Molecular / Capsid / Norovirus / Capsid Proteins / Antibodies, Neutralizing / Single-Domain Antibodies Type of study: Prognostic_studies Language: En Journal: PLoS Pathog Year: 2017 Type: Article Affiliation country: Germany

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