Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection.

Song, Zhongbao; Zhang, Qiaoya; Liu, Xuewei; Bai, Juan; Zhao, Yongxiang; Wang, Xianwei; Jiang, Ping

Song, Zhongbao; Zhang, Qiaoya; Liu, Xuewei; Bai, Juan; Zhao, Yongxiang; Wang, Xianwei; Jiang, Ping.

Affiliation

Song Z; Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Zhang Q; Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Liu X; Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Bai J; Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Zhao Y; Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Wang X; Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Jiang P; Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.

Vet Microbiol ; 210: 153-161, 2017 Oct.

Article in En | MEDLINE | ID: mdl-29103685

Subject(s)

Antiviral Agents/metabolism; Porcine Reproductive and Respiratory Syndrome/prevention & control; Porcine respiratory and reproductive syndrome virus/drug effects; Steroid Hydroxylases/metabolism; Virus Internalization/drug effects; Animals; Cells, Cultured; Chlorocebus aethiops; Cholesterol/metabolism; Hydroxycholesterols/metabolism; Interferon-alpha/metabolism; Macrophages, Alveolar/virology; Mutation; Porcine Reproductive and Respiratory Syndrome/virology; Porcine respiratory and reproductive syndrome virus/physiology; Steroid Hydroxylases/genetics; Swine; Virus Replication/drug effects

Key words

25-Hydroxycholesterol; Antiviral; Cholesterol 25-hydroxylase; Interferon; Porcine reproductive and respiratory syndrome virus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Steroid Hydroxylases / Porcine respiratory and reproductive syndrome virus / Porcine Reproductive and Respiratory Syndrome / Virus Internalization Limits: Animals Language: En Journal: Vet Microbiol Year: 2017 Type: Article Affiliation country: China

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