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Chemical and Biophysical Characteristics of Monoclonal Antibody Solutions Containing Aggregates Formed during Metal Catalyzed Oxidation.
Narhi, Linda O; Luo, Quanzhou; Wypych, Jette; Torosantucci, Riccardo; Hawe, Andrea; Fujimori, Kiyoshi; Nashed-Samuel, Yasser; Jawa, Vibha; Joubert, Marisa K; Jiskoot, Wim.
Affiliation
  • Narhi LO; Attribute Sciences, Amgen Inc., One Amgen Center Dr, M/S 30-1-B, Thousand Oaks, California, 91320, USA. lnarhi@amgen.com.
  • Luo Q; Attribute Sciences, Amgen Inc., One Amgen Center Dr, M/S 30-1-B, Thousand Oaks, California, 91320, USA.
  • Wypych J; Attribute Sciences, Amgen Inc., One Amgen Center Dr, M/S 30-1-B, Thousand Oaks, California, 91320, USA.
  • Torosantucci R; Coriolis Pharma, Martinsried, Munich, Germany.
  • Hawe A; Coriolis Pharma, Martinsried, Munich, Germany.
  • Fujimori K; Attribute Sciences, Amgen Inc., One Amgen Center Dr, M/S 30-1-B, Thousand Oaks, California, 91320, USA.
  • Nashed-Samuel Y; Attribute Sciences, Amgen Inc., One Amgen Center Dr, M/S 30-1-B, Thousand Oaks, California, 91320, USA.
  • Jawa V; Medical Sciences, Amgen Inc., Thousand Oaks, California, 91320, USA.
  • Joubert MK; Currently at Merck, Kenilworth, NJ, USA.
  • Jiskoot W; Attribute Sciences, Amgen Inc., One Amgen Center Dr, M/S 30-1-B, Thousand Oaks, California, 91320, USA.
Pharm Res ; 34(12): 2817-2828, 2017 Dec.
Article in En | MEDLINE | ID: mdl-29110285
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Copper / Protein Aggregates / Rituximab / Antineoplastic Agents, Immunological / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Pharm Res Year: 2017 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Copper / Protein Aggregates / Rituximab / Antineoplastic Agents, Immunological / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Pharm Res Year: 2017 Type: Article Affiliation country: United States