Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease.

Mann, Aman P; Scodeller, Pablo; Hussain, Sazid; Braun, Gary B; Mölder, Tarmo; Toome, Kadri; Ambasudhan, Rajesh; Teesalu, Tambet; Lipton, Stuart A; Ruoslahti, Erkki

Mann, Aman P; Scodeller, Pablo; Hussain, Sazid; Braun, Gary B; Mölder, Tarmo; Toome, Kadri; Ambasudhan, Rajesh; Teesalu, Tambet; Lipton, Stuart A; Ruoslahti, Erkki.

Affiliation

Mann AP; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Scodeller P; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Hussain S; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, 50411, Estonia.
Braun GB; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Mölder T; AivoCode Inc., La Jolla, CA, 92037, USA.
Toome K; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Ambasudhan R; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, 50411, Estonia.
Teesalu T; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, 50411, Estonia.
Lipton SA; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA.
Ruoslahti E; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, 50411, Estonia.

Nat Commun ; 8(1): 1403, 2017 11 10.

Article in En | MEDLINE | ID: mdl-29123083

Subject(s)

Alzheimer Disease/metabolism; Peptides, Cyclic/metabolism; Alzheimer Disease/etiology; Alzheimer Disease/pathology; Amyloid beta-Protein Precursor/metabolism; Animals; Astrocytes/metabolism; Astrocytes/pathology; Brain/blood supply; Brain/metabolism; Brain/pathology; Connective Tissue Growth Factor/metabolism; Disease Models, Animal; Hippocampus/blood supply; Hippocampus/metabolism; Hippocampus/pathology; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Peptide Library; Peptides, Cyclic/chemistry; Protein Binding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Alzheimer Disease Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Type: Article Affiliation country: United States

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