The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart.

Bidwell, Philip A; Haghighi, Kobra; Kranias, Evangelia G

Bidwell, Philip A; Haghighi, Kobra; Kranias, Evangelia G.

Affiliation

Bidwell PA; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.
Haghighi K; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.
Kranias EG; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Molecular Biology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 115 27 Athens, Greece. Electronic address: Litsa.Kranias@uc.edu.

J Biol Chem ; 293(1): 359-367, 2018 01 05.

Article in En | MEDLINE | ID: mdl-29150445

Subject(s)

Myocardial Contraction/drug effects; Proteins/metabolism; Proteins/physiology; Animals; Apoptosis/drug effects; Calcium/metabolism; Calcium Signaling/drug effects; Calcium-Binding Proteins/pharmacology; Endoplasmic Reticulum/metabolism; Intracellular Signaling Peptides and Proteins; Isoproterenol/pharmacology; Mice; Mice, Knockout; Muscle Contraction/physiology; Myocardial Contraction/physiology; Myocytes, Cardiac/metabolism; Phosphorylation; Protein Binding; Sarcoplasmic Reticulum/metabolism; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism

Key words

HAX-1; SERCA2a; calcium ATPase; calcium transport; cardiac muscle; cardiomyocyte; cardiovascular; contractility; heart; phospholamban

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Myocardial Contraction Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2018 Type: Article

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