Tris acetylacetonate aluminium(III) induces osmotic fragility and acanthocyte formation in suspended erythrocytes.
Toxicol Lett
; 45(1): 15-21, 1989 Jan.
Article
in En
| MEDLINE
| ID: mdl-2916246
ABSTRACT
Tris acetylacetonate aluminium(III) (Al(acac)3), dissolved in water, is effective in producing osmotic fragility in suspended erythrocytes in the concentration range of 0.034-0.34 mmol/l. Water solutions of Tris maltolate aluminium(III) (Al(malt)3) and aluminium lactate (Al(lac)3) are also effective but the dose-response behavior is less pronounced. Moreover, only Al(acac)3 induces a prominent generation of acanthocytes. The stronger effects of Al(acac)3 on membrane stability are attributed to the greater solubility of this complex in the cell membrane.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organometallic Compounds
/
Osmotic Fragility
/
Pentanones
/
Erythrocyte Membrane
/
Erythrocytes, Abnormal
/
Aluminum
/
Acanthocytes
/
Ketones
Limits:
Animals
Language:
En
Journal:
Toxicol Lett
Year:
1989
Type:
Article
Affiliation country:
Italy