Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.

Sysol, Justin R; Chen, Jiwang; Singla, Sunit; Zhao, Shuangping; Comhair, Suzy; Natarajan, Viswanathan; Machado, Roberto F

Sysol, Justin R; Chen, Jiwang; Singla, Sunit; Zhao, Shuangping; Comhair, Suzy; Natarajan, Viswanathan; Machado, Roberto F.

Affiliation

Sysol JR; Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Chen J; Department of Pharmacology, University of Illinois at Chicago , Chicago, Illinois.
Singla S; Medical Scientist Training Program, University of Illinois at Chicago , Chicago, Illinois.
Zhao S; Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Comhair S; Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Natarajan V; Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Machado RF; Cleveland Clinic , Cleveland, Ohio.

Am J Physiol Lung Cell Mol Physiol ; 314(3): L461-L472, 2018 03 01.

Article in En | MEDLINE | ID: mdl-29167124

Subject(s)

Hypertension, Pulmonary/pathology; Hypoxia/physiopathology; MicroRNAs/genetics; Muscle, Smooth, Vascular/pathology; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Pulmonary Artery/pathology; Vascular Remodeling; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Humans; Hypertension, Pulmonary/etiology; Hypertension, Pulmonary/metabolism; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular/metabolism; Phosphotransferases (Alcohol Group Acceptor)/genetics; Pulmonary Artery/metabolism

Key words

hypoxia; micro-RNA-1; pulmonary hypertension; sphingosine kinase 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Artery / Phosphotransferases (Alcohol Group Acceptor) / MicroRNAs / Vascular Remodeling / Hypertension, Pulmonary / Hypoxia / Muscle, Smooth, Vascular Type of study: Etiology_studies Limits: Animals / Humans / Male Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2018 Type: Article

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