A Solid-State Conceptualization of Information Transfer from Gene to Message to Protein.

Kato, Masato; McKnight, Steven L

Kato, Masato; McKnight, Steven L.

Affiliation

Kato M; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9152, USA; email: steven.mcknight@utsouthwestern.edu.
McKnight SL; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9152, USA; email: steven.mcknight@utsouthwestern.edu.

Annu Rev Biochem ; 87: 351-390, 2018 06 20.

Article in En | MEDLINE | ID: mdl-29195049

Subject(s)

Intrinsically Disordered Proteins/genetics; Intrinsically Disordered Proteins/metabolism; Models, Biological; Animals; Cytoplasmic Granules/genetics; Cytoplasmic Granules/metabolism; Gene Expression; Heredodegenerative Disorders, Nervous System/genetics; Heredodegenerative Disorders, Nervous System/metabolism; Humans; Hydrogels; Intrinsically Disordered Proteins/chemistry; Models, Molecular; Mutation; Protein Interaction Domains and Motifs; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA-Binding Protein FUS/chemistry; RNA-Binding Protein FUS/genetics; RNA-Binding Protein FUS/metabolism

Key words

aliphatic alcohols; hydrogels; intrinsically disordered proteins; labile cross-ß interactions; liquid-like droplets; low complexity domains; phase transitions

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Intrinsically Disordered Proteins / Models, Biological Limits: Animals / Humans Language: En Journal: Annu Rev Biochem Year: 2018 Type: Article

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