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Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition.
Dalton, Samuel E; Dittus, Lars; Thomas, Daniel A; Convery, Máire A; Nunes, Joao; Bush, Jacob T; Evans, John P; Werner, Thilo; Bantscheff, Marcus; Murphy, John A; Campos, Sebastien.
Affiliation
  • Dalton SE; Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde , 295 Cathedral Street, Glasgow G1 1XL, U.K.
  • Dittus L; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Thomas DA; Cellzome GmbH , a GSK company, Meyerhofstraße 1, Heidelberg 69117, Germany.
  • Convery MA; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Nunes J; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Bush JT; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Evans JP; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Werner T; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Bantscheff M; Cellzome GmbH , a GSK company, Meyerhofstraße 1, Heidelberg 69117, Germany.
  • Murphy JA; Cellzome GmbH , a GSK company, Meyerhofstraße 1, Heidelberg 69117, Germany.
  • Campos S; Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde , 295 Cathedral Street, Glasgow G1 1XL, U.K.
J Am Chem Soc ; 140(3): 932-939, 2018 01 24.
Article in En | MEDLINE | ID: mdl-29232121
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 3-Kinases / Protein Kinase Inhibitors / Phosphoinositide-3 Kinase Inhibitors / Lysine Limits: Animals / Humans Language: En Journal: J Am Chem Soc Year: 2018 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 3-Kinases / Protein Kinase Inhibitors / Phosphoinositide-3 Kinase Inhibitors / Lysine Limits: Animals / Humans Language: En Journal: J Am Chem Soc Year: 2018 Type: Article Affiliation country: United kingdom