Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig.

Tsujikawa, Shogo; Matsuura, Tadashi; Hori, Kotaro; Mori, Takashi; Kuno, Miyuki; Nishikawa, Kiyonobu

Tsujikawa, Shogo; Matsuura, Tadashi; Hori, Kotaro; Mori, Takashi; Kuno, Miyuki; Nishikawa, Kiyonobu.

Affiliation

Tsujikawa S; From the Departments of Anesthesiology.
Matsuura T; From the Departments of Anesthesiology.
Hori K; From the Departments of Anesthesiology.
Mori T; From the Departments of Anesthesiology.
Kuno M; Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Nishikawa K; From the Departments of Anesthesiology.

Anesth Analg ; 126(4): 1159-1169, 2018 04.

Article in En | MEDLINE | ID: mdl-29239964

Subject(s)

Acid-Base Equilibrium/drug effects; Alkalies/administration & dosage; Amitriptyline; Heart Diseases/drug therapy; Phospholipids/administration & dosage; Sodium Bicarbonate/administration & dosage; Soybean Oil/administration & dosage; Action Potentials/drug effects; Animals; Arterial Pressure/drug effects; Cardiotoxicity; Disease Models, Animal; Emulsions/administration & dosage; Guinea Pigs; Heart Diseases/blood; Heart Diseases/physiopathology; Heart Rate/drug effects; Hydrogen-Ion Concentration; Infusions, Intravenous; Isolated Heart Preparation; Kinetics; Male; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Recovery of Function; Sodium/metabolism; Ventricular Function, Left/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phospholipids / Acid-Base Equilibrium / Soybean Oil / Sodium Bicarbonate / Alkalies / Heart Diseases / Amitriptyline Type of study: Prognostic_studies Limits: Animals Language: En Journal: Anesth Analg Year: 2018 Type: Article

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