Silencing of secretory clusterin sensitizes NSCLC cells to V-ATPase inhibitors by downregulating survivin.

Kim, Young-Sun; Jin, Hyeon-Ok; Hong, Sung-Eun; Song, Jie-Young; Hwang, Chang-Sun; Park, In-Chul

Kim, Young-Sun; Jin, Hyeon-Ok; Hong, Sung-Eun; Song, Jie-Young; Hwang, Chang-Sun; Park, In-Chul.

Affiliation

Kim YS; Human Resource Biobank, Cheil General Hospital & Women's Healthcare Center, DanKook University College of Medicine, 17, Seoae-ro 1-gil, Jung-gu, Seoul, 04619, Republic of Korea.
Jin HO; KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul, 01812, Republic of Korea.
Hong SE; Division of Basic Radiation Bioscience, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul, 01812, Republic of Korea.
Song JY; Division of Applied Radiation Bioscience, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul, 01812, Republic of Korea.
Hwang CS; Human Resource Biobank, Cheil General Hospital & Women's Healthcare Center, DanKook University College of Medicine, 17, Seoae-ro 1-gil, Jung-gu, Seoul, 04619, Republic of Korea. Electronic address: sunmaker7@hanmail.net.
Park IC; Division of Basic Radiation Bioscience, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul, 01812, Republic of Korea. Electronic address: parkic@kirams.re.kr.

Biochem Biophys Res Commun ; 495(2): 2004-2009, 2018 01 08.

Article in En | MEDLINE | ID: mdl-29253572

Subject(s)

Antineoplastic Agents/administration & dosage; Carcinoma, Non-Small-Cell Lung/therapy; Clusterin/genetics; Genetic Therapy/methods; Inhibitor of Apoptosis Proteins/metabolism; Lung Neoplasms/therapy; Vacuolar Proton-Translocating ATPases/antagonists & inhibitors; A549 Cells; Apoptosis/drug effects; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/pathology; Cell Survival/drug effects; Combined Modality Therapy/methods; Down-Regulation/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Gene Expression Regulation, Neoplastic/genetics; Gene Silencing; Humans; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Survivin

Key words

AKT; Clusterin; PI3K; Survivin; V-ATPase; mTOR

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Carcinoma, Non-Small-Cell Lung / Vacuolar Proton-Translocating ATPases / Inhibitor of Apoptosis Proteins / Clusterin / Lung Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2018 Type: Article

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