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The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
Ruiz-Moreno, Juan S; Hamann, Lutz; Shah, Javeed A; Verbon, Annelies; Mockenhaupt, Frank P; Puzianowska-Kuznicka, Monika; Naujoks, Jan; Sander, Leif E; Witzenrath, Martin; Cambier, John C; Suttorp, Norbert; Schumann, Ralf R; Jin, Lei; Hawn, Thomas R; Opitz, Bastian.
Affiliation
  • Ruiz-Moreno JS; Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Hamann L; Institute of Microbiology and Hygiene, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health Berlin, Berlin, Germany.
  • Shah JA; Department of Medicine, University of Washington, Seattle, Washington, United states of America.
  • Verbon A; VA Puget Sound Health Care System, Seattle, Washington, United states of America.
  • Mockenhaupt FP; Department of Medical Microbiology and Infectious diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Puzianowska-Kuznicka M; Institute of Tropical Medicine and International Health, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Naujoks J; Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
  • Sander LE; Department of Geriatrics and Gerontology, Medical Centre of Postgraduate Education, Warsaw, Poland.
  • Witzenrath M; Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Cambier JC; Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Suttorp N; German Center for Lung Research (DZL), Germany.
  • Schumann RR; Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Jin L; German Center for Lung Research (DZL), Germany.
  • Hawn TR; CAPNETZ STIFTUNG, Hannover, Germany.
  • Opitz B; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
PLoS Pathog ; 14(1): e1006829, 2018 01.
Article in En | MEDLINE | ID: mdl-29298342
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Legionnaires' Disease / Legionella pneumophila / Immunity, Innate / Membrane Proteins / Anti-Bacterial Agents / Nucleotidyltransferases Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: PLoS Pathog Year: 2018 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Legionnaires' Disease / Legionella pneumophila / Immunity, Innate / Membrane Proteins / Anti-Bacterial Agents / Nucleotidyltransferases Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: PLoS Pathog Year: 2018 Type: Article Affiliation country: Germany