Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.

Du, Kuo; Hyun, Jeongeun; Premont, Richard T; Choi, Steve S; Michelotti, Gregory A; Swiderska-Syn, Marzena; Dalton, George D; Thelen, Eric; Rizi, Bahar Salimian; Jung, Youngmi; Diehl, Anna Mae

Du, Kuo; Hyun, Jeongeun; Premont, Richard T; Choi, Steve S; Michelotti, Gregory A; Swiderska-Syn, Marzena; Dalton, George D; Thelen, Eric; Rizi, Bahar Salimian; Jung, Youngmi; Diehl, Anna Mae.

Affiliation

Du K; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina.
Hyun J; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina.
Premont RT; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina.
Choi SS; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina.
Michelotti GA; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina.
Swiderska-Syn M; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina.
Dalton GD; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina.
Thelen E; XF Seahorse, Agilent Technologies, Lexington, Massachusetts.
Rizi BS; XF Seahorse, Agilent Technologies, Lexington, Massachusetts.
Jung Y; Department of Integrated Biological Science, Pusan National University, Pusan, South Korea.
Diehl AM; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina. Electronic address: annamae.diehl@duke.edu.

Gastroenterology ; 154(5): 1465-1479.e13, 2018 04.

Article in En | MEDLINE | ID: mdl-29305935

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Energy Metabolism; Glutamine/metabolism; Hedgehog Proteins/metabolism; Hepatic Stellate Cells/metabolism; Liver Cirrhosis/metabolism; Liver/metabolism; Myofibroblasts/metabolism; Phosphoproteins/metabolism; Adaptor Proteins, Signal Transducing/genetics; Animals; Case-Control Studies; Cell Cycle Proteins; Cell Proliferation; Cell Transdifferentiation; Cells, Cultured; Cellular Reprogramming; Gene Expression Regulation; Glutaminase/metabolism; Hedgehog Proteins/genetics; Hepatic Stellate Cells/pathology; Humans; Ketoglutaric Acids/metabolism; Liver/pathology; Liver Cirrhosis/genetics; Liver Cirrhosis/pathology; Liver Cirrhosis, Experimental/genetics; Liver Cirrhosis, Experimental/metabolism; Liver Cirrhosis, Experimental/pathology; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver/metabolism; Mitochondria, Liver/pathology; Myofibroblasts/pathology; Phenotype; Phosphoproteins/genetics; RNA Interference; Rats; Signal Transduction; Smoothened Receptor/genetics; Smoothened Receptor/metabolism; Time Factors; Transcription Factors; Transfection; YAP-Signaling Proteins

Key words

Fibrogenesis; Hippo Pathway; Liver Diseases; Metabolic Reprogramming

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Adaptor Proteins, Signal Transducing / Energy Metabolism / Hedgehog Proteins / Hepatic Stellate Cells / Myofibroblasts / Glutamine / Liver / Liver Cirrhosis Type of study: Observational_studies / Risk_factors_studies Language: En Journal: Gastroenterology Year: 2018 Type: Article

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