Sphingosine-1-Phosphate Receptor 1 Activation Enhances Leptomeningeal Collateral Development and Improves Outcome after Stroke in Mice.

Iwasawa, Eri; Ishibashi, Satoru; Suzuki, Motohiro; Li, FuYing; Ichijo, Masahiko; Miki, Kazunori; Yokota, Takanori

Iwasawa, Eri; Ishibashi, Satoru; Suzuki, Motohiro; Li, FuYing; Ichijo, Masahiko; Miki, Kazunori; Yokota, Takanori.

Affiliation

Iwasawa E; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.
Ishibashi S; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: t-ishibashi.nuro@tmd.ac.jp.
Suzuki M; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.
Li F; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.
Ichijo M; Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan.
Miki K; Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Yokota T; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.

J Stroke Cerebrovasc Dis ; 27(5): 1237-1251, 2018 May.

Article in En | MEDLINE | ID: mdl-29337049

Subject(s)

Cerebrovascular Circulation/drug effects; Collateral Circulation/drug effects; Infarction, Middle Cerebral Artery/drug therapy; Meninges/blood supply; Meninges/drug effects; Neovascularization, Physiologic/drug effects; Oxadiazoles/pharmacology; Receptors, Lysosphingolipid/agonists; Thiophenes/pharmacology; Animals; Blood-Brain Barrier/drug effects; Blood-Brain Barrier/metabolism; Blood-Brain Barrier/pathology; Cell Line; Disease Models, Animal; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Endothelial Cells/pathology; Infarction, Middle Cerebral Artery/metabolism; Infarction, Middle Cerebral Artery/pathology; Infarction, Middle Cerebral Artery/physiopathology; Macrophages/drug effects; Macrophages/metabolism; Male; Meninges/metabolism; Meninges/pathology; Mice, Inbred BALB C; Monocytes/drug effects; Monocytes/metabolism; Nitric Oxide Synthase Type III/metabolism; Phosphorylation; Receptors, Lysosphingolipid/metabolism; Recovery of Function; Signal Transduction/drug effects; Sphingosine-1-Phosphate Receptors; Tight Junction Proteins/metabolism; Time Factors

Key words

Collateral circulation; ischemic stroke; leptomeningeal artery; shear stress; sphingosine-1-phosphate receptor 1 (S1P1)

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Thiophenes / Cerebrovascular Circulation / Collateral Circulation / Neovascularization, Physiologic / Infarction, Middle Cerebral Artery / Receptors, Lysosphingolipid / Meninges Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Stroke Cerebrovasc Dis Journal subject: ANGIOLOGIA / CEREBRO Year: 2018 Type: Article Affiliation country: Japan

Fulltext

XML

PubMed Links

Search on Google