Bronchiolitis obliterans syndrome is associated with increased p-glycoprotein expression and loss of glucocorticoid receptor from steroid-resistant proinflammatory CD8<sup>+</sup> T cells.

Hodge, G; Hodge, S; Nguyen, P T; Yeo, A; Sarkar, P; Badiei, A; Holmes-Liew, C L; Reynolds, P N; Holmes, M

Bronchiolitis obliterans syndrome is associated with increased p-glycoprotein expression and loss of glucocorticoid receptor from steroid-resistant proinflammatory CD8⁺ T cells.

Hodge, G; Hodge, S; Nguyen, P T; Yeo, A; Sarkar, P; Badiei, A; Holmes-Liew, C L; Reynolds, P N; Holmes, M.

Affiliation

Hodge G; Lung Research Unit, Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia.
Hodge S; Department of Medicine, University of Adelaide, Adelaide, South Australia.
Nguyen PT; Lung Research Unit, Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia.
Yeo A; Department of Medicine, University of Adelaide, Adelaide, South Australia.
Sarkar P; Lung Research Unit, Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia.
Badiei A; Department of Medicine, University of Adelaide, Adelaide, South Australia.
Holmes-Liew CL; Lung Research Unit, Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia.
Reynolds PN; Lung Research Unit, Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia.
Holmes M; Lung Research Unit, Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia.

Clin Exp Immunol ; 192(2): 242-250, 2018 05.

Article in En | MEDLINE | ID: mdl-29352737

Subject(s)

ATP Binding Cassette Transporter, Subfamily B/metabolism; Bronchiolitis Obliterans/immunology; CD8-Positive T-Lymphocytes/metabolism; Lung Transplantation; Receptors, Glucocorticoid/metabolism; ATP Binding Cassette Transporter, Subfamily B/genetics; Adult; Bronchiolitis Obliterans/genetics; CD8-Positive T-Lymphocytes/drug effects; Drug Resistance; Flow Cytometry; Humans; Interferon-gamma/blood; Killer Cells, Natural/drug effects; Killer Cells, Natural/metabolism; Middle Aged; Receptors, Glucocorticoid/genetics; Steroids/administration & dosage; Tumor Necrosis Factor-alpha/blood; ATP-Binding Cassette Sub-Family B Member 4

Key words

GCR; IFN-Î³/TNF-α; Pgp; T cells; lung transplant

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bronchiolitis Obliterans / Receptors, Glucocorticoid / Lung Transplantation / CD8-Positive T-Lymphocytes / ATP Binding Cassette Transporter, Subfamily B Type of study: Risk_factors_studies Limits: Adult / Humans / Middle aged Language: En Journal: Clin Exp Immunol Year: 2018 Type: Article

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