Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias.

Takemoto, Hiroaki; Takahashi, Jun; Hyuga, Sumiko; Odaguchi, Hiroshi; Uchiyama, Nahoko; Maruyama, Takuro; Yamashita, Tadatoshi; Hyuga, Masashi; Oshima, Naohiro; Amakura, Yoshiaki; Hakamatsuka, Takashi; Goda, Yukihiro; Hanawa, Toshihiko; Kobayashi, Yoshinori

Takemoto, Hiroaki; Takahashi, Jun; Hyuga, Sumiko; Odaguchi, Hiroshi; Uchiyama, Nahoko; Maruyama, Takuro; Yamashita, Tadatoshi; Hyuga, Masashi; Oshima, Naohiro; Amakura, Yoshiaki; Hakamatsuka, Takashi; Goda, Yukihiro; Hanawa, Toshihiko; Kobayashi, Yoshinori.

Affiliation

Takemoto H; Department of Pharmacognosy, School of Pharmacy, Kitasato University.
Takahashi J; Oriental Medicine Research Center of Kitasato University.
Hyuga S; Department of Pharmacognosy, School of Pharmacy, Kitasato University.
Odaguchi H; Oriental Medicine Research Center of Kitasato University.
Uchiyama N; Oriental Medicine Research Center of Kitasato University.
Maruyama T; Oriental Medicine Research Center of Kitasato University.
Yamashita T; National Institute of Health Sciences.
Hyuga M; National Institute of Health Sciences.
Oshima N; Tokiwa Phytochemical Co., Ltd.
Amakura Y; National Institute of Health Sciences.
Hakamatsuka T; Faculty of Pharmaceutical Sciences, Tokyo University of Science.
Goda Y; College of Pharmaceutical Sciences, Matsuyama University.
Hanawa T; National Institute of Health Sciences.
Kobayashi Y; National Institute of Health Sciences.

Biol Pharm Bull ; 41(2): 247-253, 2018.

Article in En | MEDLINE | ID: mdl-29386484

Subject(s)

Anxiety/prevention & control; Arrhythmias, Cardiac/prevention & control; Dietary Supplements/adverse effects; Ephedra/chemistry; Ephedrine/adverse effects; Plant Extracts/adverse effects; Sleep Initiation and Maintenance Disorders/prevention & control; Alkaloids/analysis; Alkaloids/toxicity; Analgesics, Non-Narcotic/administration & dosage; Analgesics, Non-Narcotic/adverse effects; Analgesics, Non-Narcotic/chemistry; Animals; Animals, Outbred Strains; Anxiety/blood; Anxiety/chemically induced; Anxiety/etiology; Arrhythmias, Cardiac/blood; Arrhythmias, Cardiac/chemically induced; Arrhythmias, Cardiac/etiology; Behavior, Animal; Caffeine/poisoning; Central Nervous System Stimulants/poisoning; Dietary Supplements/analysis; Ephedrine/administration & dosage; Ephedrine/chemistry; Food Contamination; Hypnotics and Sedatives/pharmacology; Japan; Male; Mice; Pentobarbital/pharmacology; Plant Extracts/administration & dosage; Plant Extracts/chemistry; Plant Stems/chemistry; Potassium/blood; Sleep Initiation and Maintenance Disorders/blood; Sleep Initiation and Maintenance Disorders/chemically induced; Sleep Initiation and Maintenance Disorders/etiology

Key words

Ephedra Herb; adverse effect; ephedrine alkaloid; ephedrine alkaloid-free

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Arrhythmias, Cardiac / Plant Extracts / Dietary Supplements / Ephedra / Ephedrine / Sleep Initiation and Maintenance Disorders Type of study: Etiology_studies Country/Region as subject: Asia Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2018 Type: Article

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