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In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Guo, Qiang; Lehmer, Carina; Martínez-Sánchez, Antonio; Rudack, Till; Beck, Florian; Hartmann, Hannelore; Pérez-Berlanga, Manuela; Frottin, Frédéric; Hipp, Mark S; Hartl, F Ulrich; Edbauer, Dieter; Baumeister, Wolfgang; Fernández-Busnadiego, Rubén.
Affiliation
  • Guo Q; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Lehmer C; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany.
  • Martínez-Sánchez A; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Rudack T; Department of Biophysics, Ruhr University Bochum, 44780 Bochum, Germany; NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA.
  • Beck F; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Hartmann H; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany.
  • Pérez-Berlanga M; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Frottin F; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Hipp MS; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Hartl FU; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Edbauer D; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany; Ludwig-Maximilians University Munich, 81377 Munich, Germany. Electronic address: dieter.edbauer@dzne.de.
  • Baumeister W; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. Electronic address: baumeist@biochem.mpg.de.
  • Fernández-Busnadiego R; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. Electronic address: ruben@biochem.mpg.de.
Cell ; 172(4): 696-705.e12, 2018 02 08.
Article in En | MEDLINE | ID: mdl-29398115
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyglutamic Acid / Proteasome Endopeptidase Complex / Alanine / Protein Aggregates / C9orf72 Protein / Neurons Limits: Animals / Humans Language: En Journal: Cell Year: 2018 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyglutamic Acid / Proteasome Endopeptidase Complex / Alanine / Protein Aggregates / C9orf72 Protein / Neurons Limits: Animals / Humans Language: En Journal: Cell Year: 2018 Type: Article Affiliation country: Germany