Rutaecarpine Suppresses Proliferation and Promotes Apoptosis of Human Pulmonary Artery Smooth Muscle Cells in Hypoxia Possibly Through HIF-1&#945;-Dependent Pathways.

Deng, Jun; Qin, Jiajia; Cai, Yi; Zhong, Xiaobin; Zhang, Xu; Yu, Shanshan

Rutaecarpine Suppresses Proliferation and Promotes Apoptosis of Human Pulmonary Artery Smooth Muscle Cells in Hypoxia Possibly Through HIF-1α-Dependent Pathways.

Deng, Jun; Qin, Jiajia; Cai, Yi; Zhong, Xiaobin; Zhang, Xu; Yu, Shanshan.

Affiliation

Deng J; Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangdong, Guangzhou, People's Republic of China.
Qin J; Affiliated Langdong Hospital, Guangxi Medical University, Guangxi, Nanning, People's Republic of China.
Cai Y; Department of Key Laboratory of Molecular Clinical Pharmacology and Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangzhou, People's Republic of China.
Zhong X; Affiliated Langdong Hospital, Guangxi Medical University, Guangxi, Nanning, People's Republic of China.
Zhang X; Department of Pediatric Cardiology, Guangdong Cardiovascular Institute and Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangdong, Guangzhou, People's Republic of China.
Yu S; Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangdong, Guangzhou, People's Republic of China.

J Cardiovasc Pharmacol ; 71(5): 293-302, 2018 05.

Article in En | MEDLINE | ID: mdl-29438215

Subject(s)

Apoptosis/drug effects; Cell Proliferation/drug effects; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Indole Alkaloids/pharmacology; Muscle, Smooth, Vascular/drug effects; Myocytes, Smooth Muscle/drug effects; Quinazolines/pharmacology; Cell Hypoxia; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Inhibitory Concentration 50; Muscle, Smooth, Vascular/metabolism; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/metabolism; Myocytes, Smooth Muscle/pathology; Proliferating Cell Nuclear Antigen/metabolism; Pulmonary Artery/drug effects; Pulmonary Artery/metabolism; Pulmonary Artery/pathology; Signal Transduction/drug effects; Tumor Suppressor Protein p53/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Apoptosis / Indole Alkaloids / Myocytes, Smooth Muscle / Cell Proliferation / Hypoxia-Inducible Factor 1, alpha Subunit / Muscle, Smooth, Vascular Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Cardiovasc Pharmacol Year: 2018 Type: Article

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