Refrigeration, cryopreservation and pathogen inactivation: an updated perspective on platelet storage conditions.
Vox Sang
; 113(4): 317-328, 2018 May.
Article
in En
| MEDLINE
| ID: mdl-29441601
ABSTRACT
Conventional storage of platelet concentrates limits their shelf life to between 5 and 7 days due to the risk of bacterial proliferation and the development of the platelet storage lesion. Cold storage and cryopreservation of platelets may facilitate extension of the shelf life to weeks and years, and may also provide the benefit of being more haemostatically effective than conventionally stored platelets. Further, treatment of platelet concentrates with pathogen inactivation systems reduces bacterial contamination and provides a safeguard against the risk of emerging and re-emerging pathogens. While each of these alternative storage techniques is gaining traction individually, little work has been done to examine the effect of combining treatments in an effort to further improve product safety and minimize wastage. This review aims to discuss the benefits of alternative storage techniques and how they may be combined to alleviate the problems associated with conventional platelet storage.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Refrigeration
/
Blood Platelets
/
Blood Preservation
/
Cryopreservation
Limits:
Humans
Language:
En
Journal:
Vox Sang
Year:
2018
Type:
Article
Affiliation country:
Australia