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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours.
Närhi, Katja; Nagaraj, Ashwini S; Parri, Elina; Turkki, Riku; van Duijn, Petra W; Hemmes, Annabrita; Lahtela, Jenni; Uotinen, Virva; Mäyränpää, Mikko I; Salmenkivi, Kaisa; Räsänen, Jari; Linder, Nina; Trapman, Jan; Rannikko, Antti; Kallioniemi, Olli; Af Hällström, Taija M; Lundin, Johan; Sommergruber, Wolfgang; Anders, Simon; Verschuren, Emmy W.
Affiliation
  • Närhi K; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Nagaraj AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Parri E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Turkki R; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • van Duijn PW; Department of Urology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Hemmes A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Lahtela J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Uotinen V; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Mäyränpää MI; Department of Pathology, University of Helsinki, Helsinki, Finland.
  • Salmenkivi K; HUSLAB, Division of Pathology, Helsinki University Hospital, Helsinki, Finland.
  • Räsänen J; HUSLAB, Division of Pathology, Helsinki University Hospital, Helsinki, Finland.
  • Linder N; Heart and Lung Centre, Department of General Thoracic and Oesophageal Surgery, Helsinki University Hospital, Helsinki, Finland.
  • Trapman J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Rannikko A; Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam, The Netherlands.
  • Kallioniemi O; Department of Urology, Helsinki University Hospital, Helsinki, Finland.
  • Af Hällström TM; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Lundin J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Sommergruber W; Orion Corporation, Orion Pharma, Espoo, Finland.
  • Anders S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Verschuren EW; Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co. KG, Vienna, Austria.
J Pathol ; 245(1): 101-113, 2018 05.
Article in En | MEDLINE | ID: mdl-29443392
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Proto-Oncogene Proteins p21(ras) / Carcinogenesis / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Pathol Year: 2018 Type: Article Affiliation country: Finland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Proto-Oncogene Proteins p21(ras) / Carcinogenesis / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Pathol Year: 2018 Type: Article Affiliation country: Finland