Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes.

Huguet, Jade; Gaudette, Fleur; Michaud, Veronique; Turgeon, Jacques

Huguet, Jade; Gaudette, Fleur; Michaud, Veronique; Turgeon, Jacques.

Affiliation

Huguet J; a CRCHUM, University of Montreal , Montreal , Canada.
Gaudette F; b Faculty of Pharmacy , University of Montreal , Montreal , Canada.
Michaud V; a CRCHUM, University of Montreal , Montreal , Canada.
Turgeon J; a CRCHUM, University of Montreal , Montreal , Canada.

Xenobiotica ; 49(2): 187-199, 2019 Feb.

Article in En | MEDLINE | ID: mdl-29448869

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Microsomes/metabolism; Bupropion/metabolism; Butyrophenones/metabolism; Carbamates/metabolism; Chlorzoxazone/metabolism; Drug Evaluation, Preclinical/methods; Ethanolamines/metabolism; Humans; Lauric Acids/metabolism; Midazolam/metabolism; Myocardium/metabolism; Oxazines/metabolism; Piperidines/metabolism; Tolbutamide/metabolism

Key words

CYP450; LC-MSMS; cocktail; metabolism; microsome; probe; recombinant

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 Enzyme System / Microsomes Limits: Humans Language: En Journal: Xenobiotica Year: 2019 Type: Article Affiliation country: Canada

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