Synthesis of 3ß-tert-Butyldimethylsiloxy-22-phenylthio-23,24-bisnorchola-5,9(11)-diene and Reductive Nucleophilic Attack on a Branched Aliphatic Aldehyde.

Nagai, Toshiya; Hanaya, Kengo; Higashibayashi, Shuhei; Shoji, Mitsuru; Sugai, Takeshi

Nagai, Toshiya; Hanaya, Kengo; Higashibayashi, Shuhei; Shoji, Mitsuru; Sugai, Takeshi.

Affiliation

Nagai T; Department of Pharmaceutical Science, Keio University.
Hanaya K; Department of Pharmaceutical Science, Keio University.
Higashibayashi S; Department of Pharmaceutical Science, Keio University.
Shoji M; Department of Pharmaceutical Science, Keio University.
Sugai T; Department of Pharmaceutical Science, Keio University.

Chem Pharm Bull (Tokyo) ; 66(3): 334-338, 2018.

Article in En | MEDLINE | ID: mdl-29491266

Subject(s)

Aldehydes/chemistry; Androstenes/chemical synthesis; Cholic Acids/chemistry; Androstenes/chemistry; Catalysis; Cholic Acids/chemical synthesis; Coordination Complexes/chemistry; Lewis Acids/chemistry; Lithium/chemistry; Oxidation-Reduction; Stereoisomerism

Key words

ene reaction; lithium di-tert-butylbiphenyl (LiDBB); phenyl sulfide; pregna-5,9(11),17(20)-triene; reductive nucleophilic attack

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholic Acids / Aldehydes / Androstenes Language: En Journal: Chem Pharm Bull (Tokyo) Year: 2018 Type: Article

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