Elucidation of possible molecular mechanisms underlying the estrogen-induced disruption of cartilage development in zebrafish larvae.

He, Hanliang; Wang, Chunqing; Tang, Qifeng; Yang, Fan; Xu, Youjia

He, Hanliang; Wang, Chunqing; Tang, Qifeng; Yang, Fan; Xu, Youjia.

Affiliation

He H; Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Wang C; Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Tang Q; The Benq Medical Center of Suzhou, Suzhou, 215000, China.
Yang F; Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Xu Y; Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. Electronic address: xuyoujia@suda.edu.cn.

Toxicol Lett ; 289: 22-27, 2018 Jun 01.

Article in En | MEDLINE | ID: mdl-29499231

Subject(s)

Cartilage/drug effects; Chondrogenesis/drug effects; Craniofacial Abnormalities/chemically induced; Estrogens/adverse effects; Gene Expression Regulation, Developmental/drug effects; Models, Biological; Teratogens/toxicity; Animals; Apoptosis/drug effects; Bone Development/drug effects; Bone Resorption/chemically induced; Bone Resorption/metabolism; Cartilage/abnormalities; Cartilage/metabolism; Cell Cycle/drug effects; Collagen/genetics; Collagen/metabolism; Craniofacial Abnormalities/metabolism; Extracellular Matrix/drug effects; Extracellular Matrix/metabolism; Gene Expression Profiling; Gene Ontology; High-Throughput Nucleotide Sequencing; Larva; Signal Transduction/drug effects; Zebrafish; Zebrafish Proteins/chemistry; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Key words

Cartilage defect; Estrogen; Extracellular matrix; RNA deep sequencing; Zebrafish

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Teratogens / Cartilage / Gene Expression Regulation, Developmental / Craniofacial Abnormalities / Chondrogenesis / Estrogens / Models, Biological Limits: Animals Language: En Journal: Toxicol Lett Year: 2018 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google