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Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
O'Reilly, Lorraine A; Putoczki, Tracy L; Mielke, Lisa A; Low, Jun T; Lin, Ann; Preaudet, Adele; Herold, Marco J; Yaprianto, Kelvin; Tai, Lin; Kueh, Andrew; Pacini, Guido; Ferrero, Richard L; Gugasyan, Raffi; Hu, Yifang; Christie, Michael; Wilcox, Stephen; Grumont, Raelene; Griffin, Michael D W; O'Connor, Liam; Smyth, Gordon K; Ernst, Mathias; Waring, Paul; Gerondakis, Steve; Strasser, Andreas.
Affiliation
  • O'Reilly LA; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: oreilly@wehi.edu.au.
  • Putoczki TL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Mielke LA; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Low JT; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Lin A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  • Preaudet A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  • Herold MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Yaprianto K; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
  • Tai L; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  • Kueh A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Pacini G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  • Ferrero RL; Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.
  • Gugasyan R; Healthy Ageing, Life Sciences Discipline, The Burnet Institute, Melbourne, Victoria 3004, Australia; Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.
  • Hu Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  • Christie M; Centre for Translational Pathology, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Wilcox S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Grumont R; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia; Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Victoria, Australia.
  • Griffin MDW; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, 3010, Australia; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, Australia.
  • O'Connor L; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Smyth GK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria 3010, Australia.
  • Ernst M; Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Heidelberg, Victoria 3084, Australia.
  • Waring P; Department of Pathology, The University of Melbourne, Parkville 3052, Victoria, Australia.
  • Gerondakis S; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia; Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Victoria, Australia.
  • Strasser A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: strasser@wehi.edu.au.
Immunity ; 48(3): 570-583.e8, 2018 03 20.
Article in En | MEDLINE | ID: mdl-29562203
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Gene Expression Regulation, Neoplastic / NF-kappa B / STAT1 Transcription Factor / Inflammation Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Gene Expression Regulation, Neoplastic / NF-kappa B / STAT1 Transcription Factor / Inflammation Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article