Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.

Dasgupta, Subhamoy; Rajapakshe, Kimal; Zhu, Bokai; Nikolai, Bryan C; Yi, Ping; Putluri, Nagireddy; Choi, Jong Min; Jung, Sung Y; Coarfa, Cristian; Westbrook, Thomas F; Zhang, Xiang H-F; Foulds, Charles E; Tsai, Sophia Y; Tsai, Ming-Jer; O'Malley, Bert W

Dasgupta, Subhamoy; Rajapakshe, Kimal; Zhu, Bokai; Nikolai, Bryan C; Yi, Ping; Putluri, Nagireddy; Choi, Jong Min; Jung, Sung Y; Coarfa, Cristian; Westbrook, Thomas F; Zhang, Xiang H-F; Foulds, Charles E; Tsai, Sophia Y; Tsai, Ming-Jer; O'Malley, Bert W.

Affiliation

Dasgupta S; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. subhamoy.dasgupta@roswellpark.org.
Rajapakshe K; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. subhamoy.dasgupta@roswellpark.org.
Zhu B; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Nikolai BC; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Yi P; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Putluri N; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Choi JM; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Jung SY; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Coarfa C; Verna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
Westbrook TF; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Zhang XH; Verna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
Foulds CE; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Tsai SY; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Tsai MJ; Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
O'Malley BW; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

Nature ; 556(7700): 249-254, 2018 04.

Article in En | MEDLINE | ID: mdl-29615789

Subject(s)

Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Gene Expression Regulation, Neoplastic; Glucose/metabolism; Nuclear Receptor Coactivator 3/metabolism; Phosphofructokinase-2/metabolism; Transcriptional Activation; Activating Transcription Factor 4/metabolism; Animals; Breast Neoplasms/enzymology; Breast Neoplasms/pathology; Cell Line, Tumor; Female; Glycolysis; Humans; Lung Neoplasms/prevention & control; Lung Neoplasms/secondary; Mice; Neoplasm Metastasis; Pentose Phosphate Pathway; Phosphorylation; Phosphoserine/metabolism; Prognosis; Purines/biosynthesis; Purines/metabolism; RNA Interference; Receptors, Estrogen/metabolism; Transketolase/metabolism; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Gene Expression Regulation, Neoplastic / Transcriptional Activation / Phosphofructokinase-2 / Nuclear Receptor Coactivator 3 / Glucose Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2018 Type: Article Affiliation country: United States

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