Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

Soares, Pedro; Lucas, Xavier; Ciulli, Alessio

Soares, Pedro; Lucas, Xavier; Ciulli, Alessio.

Affiliation

Soares P; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
Lucas X; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
Ciulli A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK. Electronic address: a.ciulli@dundee.ac.uk.

Bioorg Med Chem ; 26(11): 2992-2995, 2018 07 15.

Article in En | MEDLINE | ID: mdl-29650462

Subject(s)

Hydroxyproline/chemistry; Thioamides/chemistry; Von Hippel-Lindau Tumor Suppressor Protein/chemistry; Crystallography, X-Ray; Drug Stability; Humans; Hydrogen Bonding; Ligands; Protein Binding

Key words

PROTACs; Protein-ligand interactions; Thioamides; VHL ligands; n â π(∗) interaction

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioamides / Von Hippel-Lindau Tumor Suppressor Protein / Hydroxyproline Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google