Mechanistic studies of a small-molecule modulator of SMN2 splicing.

Wang, Jingxin; Schultz, Peter G; Johnson, Kristen A

Wang, Jingxin; Schultz, Peter G; Johnson, Kristen A.

Affiliation

Wang J; California Institute for Biomedical Research, La Jolla, CA 92037.
Schultz PG; California Institute for Biomedical Research, La Jolla, CA 92037; schultz@scripps.edu kjohnson@calibr.org.
Johnson KA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.

Proc Natl Acad Sci U S A ; 115(20): E4604-E4612, 2018 05 15.

Article in En | MEDLINE | ID: mdl-29712837

Subject(s)

Alternative Splicing; DNA Helicases/genetics; DNA-Binding Proteins/genetics; Muscular Atrophy, Spinal/genetics; RNA Precursors/genetics; RNA-Binding Proteins/genetics; Small Molecule Libraries/pharmacology; Trans-Activators/genetics; DNA Helicases/chemistry; DNA Helicases/metabolism; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Exons; Humans; Muscular Atrophy, Spinal/metabolism; Muscular Atrophy, Spinal/pathology; Nucleic Acid Conformation; Proteomics; RNA-Binding Proteins/chemistry; RNA-Binding Proteins/metabolism; Survival of Motor Neuron 2 Protein/chemistry; Survival of Motor Neuron 2 Protein/genetics; Survival of Motor Neuron 2 Protein/metabolism; Trans-Activators/chemistry; Trans-Activators/metabolism

Key words

RG-7916; RNA binding; RNA splicing; chemical proteomics; spinal muscular atrophy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscular Atrophy, Spinal / RNA Precursors / Trans-Activators / RNA-Binding Proteins / Alternative Splicing / DNA Helicases / DNA-Binding Proteins / Small Molecule Libraries Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article

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