Peripheral PDGFR&#945;<sup>+</sup>gp38<sup>+</sup> mesenchymal cells support the differentiation of fetal liver-derived ILC2.

Koga, Satoshi; Hozumi, Katsuto; Hirano, Ken-Ichi; Yazawa, Masaki; Terooatea, Tommy; Minoda, Aki; Nagasawa, Takashi; Koyasu, Shigeo; Moro, Kazuyo

Peripheral PDGFRα⁺gp38⁺ mesenchymal cells support the differentiation of fetal liver-derived ILC2.

Koga, Satoshi; Hozumi, Katsuto; Hirano, Ken-Ichi; Yazawa, Masaki; Terooatea, Tommy; Minoda, Aki; Nagasawa, Takashi; Koyasu, Shigeo; Moro, Kazuyo.

Affiliation

Koga S; Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Hozumi K; Division of Immunobiology, Department of Medical Life Science, Department of Supramolecular Biology, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Hirano KI; Department of Immunology, Tokai University School of Medicine, Isehara, Japan.
Yazawa M; Department of Immunology, Tokai University School of Medicine, Isehara, Japan.
Terooatea T; Department of Immunology, Tokai University School of Medicine, Isehara, Japan.
Minoda A; Department of Biochemistry, Tokai University, Hiratsuka, Japan.
Nagasawa T; Epigenome Technology Exploration Unit, RIKEN Center for Life Science Technologies, Yokohama, Japan.
Koyasu S; Epigenome Technology Exploration Unit, RIKEN Center for Life Science Technologies, Yokohama, Japan.
Moro K; Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan.

J Exp Med ; 215(6): 1609-1626, 2018 06 04.

Article in En | MEDLINE | ID: mdl-29728440

Subject(s)

Cell Differentiation; Immunity, Innate; Liver/cytology; Liver/embryology; Lymphocytes/cytology; Membrane Glycoproteins/metabolism; Mesenchymal Stem Cells/cytology; Receptor, Platelet-Derived Growth Factor alpha/metabolism; Animals; B-Lymphocytes/cytology; B-Lymphocytes/drug effects; Cell Differentiation/drug effects; Cell Lineage/drug effects; Fetus/cytology; GATA3 Transcription Factor/metabolism; Immunity, Innate/drug effects; Interleukin-7/pharmacology; Intracellular Signaling Peptides and Proteins/metabolism; Lymphocytes/drug effects; Lymphocytes/metabolism; Lymphoid Progenitor Cells/cytology; Lymphoid Progenitor Cells/metabolism; Membrane Proteins/metabolism; Mesenchymal Stem Cells/drug effects; Mesenchymal Stem Cells/metabolism; Mesentery/embryology; Mice, Inbred C57BL; Receptors, Notch/metabolism; Signal Transduction; Stromal Cells/cytology; Stromal Cells/metabolism; T-Lymphocytes/cytology; T-Lymphocytes/drug effects; Thymus Gland/cytology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Lymphocytes / Cell Differentiation / Receptor, Platelet-Derived Growth Factor alpha / Mesenchymal Stem Cells / Immunity, Innate / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Exp Med Year: 2018 Type: Article Affiliation country: Japan

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