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The Polycomb-Dependent Epigenome Controls ß Cell Dysfunction, Dedifferentiation, and Diabetes.
Lu, Tess Tsai-Hsiu; Heyne, Steffen; Dror, Erez; Casas, Eduard; Leonhardt, Laura; Boenke, Thorina; Yang, Chih-Hsiang; Arrigoni, Laura; Dalgaard, Kevin; Teperino, Raffaele; Enders, Lennart; Selvaraj, Madhan; Ruf, Marius; Raja, Sunil J; Xie, Huafeng; Boenisch, Ulrike; Orkin, Stuart H; Lynn, Francis C; Hoffman, Brad G; Grün, Dominic; Vavouri, Tanya; Lempradl, Adelheid M; Pospisilik, J Andrew.
Affiliation
  • Lu TT; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Heyne S; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Dror E; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Casas E; Program for Predictive and Personalized Medicine of Cancer (PMPPC), Institute Germans Trias i Pujol, UAB, Badalona 08916, Spain.
  • Leonhardt L; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Boenke T; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Yang CH; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Sagar; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Arrigoni L; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Dalgaard K; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Teperino R; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Enders L; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Selvaraj M; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Ruf M; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Raja SJ; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Xie H; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Boenisch U; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Orkin SH; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Lynn FC; Diabetes Research Program, BC Children's Hospital Research Institute, A4-184, 950 West 28 Avenue, Vancouver, BC V5Z 4H4, Canada.
  • Hoffman BG; Diabetes Research Program, BC Children's Hospital Research Institute, A4-184, 950 West 28 Avenue, Vancouver, BC V5Z 4H4, Canada.
  • Grün D; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Vavouri T; Program for Predictive and Personalized Medicine of Cancer (PMPPC), Institute Germans Trias i Pujol, UAB, Badalona 08916, Spain; Josep Carreras Leukaemia Research Institute (IJC), Campus ICO - Germans Trias i Pujol, Badalona 08916, Spain.
  • Lempradl AM; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
  • Pospisilik JA; Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany. Electronic address: pospisilik@ie-freiburg.mpg.de.
Cell Metab ; 27(6): 1294-1308.e7, 2018 Jun 05.
Article in En | MEDLINE | ID: mdl-29754954
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Gene Silencing / Diabetes Mellitus, Type 2 / Insulin-Secreting Cells / Diet, High-Fat / Polycomb Repressive Complex 2 Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2018 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Gene Silencing / Diabetes Mellitus, Type 2 / Insulin-Secreting Cells / Diet, High-Fat / Polycomb Repressive Complex 2 Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2018 Type: Article Affiliation country: Germany