Critical evaluation of 2-ethylhexyl acrylate dermal carcinogenicity studies using contemporary criteria.

Murphy, Sandra; Ellis-Hutchings, Robert; Finch, Lavorgie; Welz, Stefanie; Wiench, Karin

Murphy, Sandra; Ellis-Hutchings, Robert; Finch, Lavorgie; Welz, Stefanie; Wiench, Karin.

Affiliation

Murphy S; Kennett Square, PA, 19348, United States.
Ellis-Hutchings R; The Dow Chemical Company, Midland, MI, 48674, United States. Electronic address: REllis-hutchings@dow.comc.
Finch L; Arkema Inc., King of Prussia, PA, 19406, United States.
Welz S; BASF SE, Ludwigshafen am Rhein, Germany.
Wiench K; BASF SE, Ludwigshafen am Rhein, Germany.

Toxicol Lett ; 294: 205-211, 2018 Sep 15.

Article in En | MEDLINE | ID: mdl-29775721

Subject(s)

Acrylates/toxicity; Air Pollutants, Occupational/toxicity; Carcinogenesis/drug effects; Skin Neoplasms/chemically induced; Skin/drug effects; Acrylates/administration & dosage; Animals; Dose-Response Relationship, Drug; Guidelines as Topic; Humans; Immunocompromised Host/drug effects; Maximum Tolerated Dose; Mutagenicity Tests/standards; Mutagenicity Tests/trends; Reproducibility of Results; Risk Assessment; Skin/immunology; Skin/pathology; Skin Neoplasms/immunology; Skin Neoplasms/pathology; Species Specificity; Toxicity Tests, Acute/standards; Toxicity Tests, Acute/trends; Toxicity Tests, Chronic/standards; Toxicity Tests, Chronic/trends

Key words

2-Ethylhexyl acrylate; C3H/HeJ mouse; Dermal carcinogenesis; Maximum tolerated dose; Nongenotoxic irritant; Strain selection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Skin Neoplasms / Acrylates / Air Pollutants, Occupational / Carcinogenesis Type of study: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Toxicol Lett Year: 2018 Type: Article Affiliation country: United States

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