SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.

Fernandes, Sandra; Srivastava, Neetu; Sudan, Raki; Middleton, Frank A; Shergill, Amandeep K; Ryan, James C; Kerr, William G

Fernandes, Sandra; Srivastava, Neetu; Sudan, Raki; Middleton, Frank A; Shergill, Amandeep K; Ryan, James C; Kerr, William G.

Affiliation

Fernandes S; Department of Microbiology and Immunology, Upstate Medical University, Syracuse, NY, United States.
Srivastava N; Department of Microbiology and Immunology, Upstate Medical University, Syracuse, NY, United States.
Sudan R; Department of Microbiology and Immunology, Upstate Medical University, Syracuse, NY, United States.
Middleton FA; Department of Neuroscience and Physiology, Upstate Medical University, Syracuse, NY, United States.
Shergill AK; Department of Biochemistry and Molecular Biology, Upstate Medical University, Syracuse, NY, United States.
Ryan JC; Department of Psychiatry and Behavioral Sciences, Upstate Medical University, Syracuse, NY, United States.
Kerr WG; Department of Medicine, University of California San Francisco, San Francisco, CA, United States.

Front Immunol ; 9: 1100, 2018.

Article in En | MEDLINE | ID: mdl-29872435

Subject(s)

Inflammatory Bowel Diseases/etiology; Lymphocyte Count; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/deficiency; T-Lymphocytes/immunology; Alleles; Animals; Autophagy-Related Proteins/genetics; Biomarkers; Computational Biology/methods; Crohn Disease/blood; Crohn Disease/diagnosis; Crohn Disease/etiology; Crohn Disease/metabolism; Disease Models, Animal; Disease Susceptibility; Exons; Gene Expression Profiling; Gene Expression Regulation; Humans; Inflammatory Bowel Diseases/blood; Inflammatory Bowel Diseases/diagnosis; Inflammatory Bowel Diseases/metabolism; Leukocytes, Mononuclear/immunology; Leukocytes, Mononuclear/metabolism; Mice; Mice, Transgenic; Mutation; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/genetics; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/metabolism; Proteasome Endopeptidase Complex/metabolism; Severity of Illness Index; T-Lymphocytes/metabolism; Exome Sequencing

Key words

ATG16L1; Crohn's disease; INPP5D; SHIP1; T cells; fusion transcript; human inflammatory bowel disease

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Inflammatory Bowel Diseases / Lymphocyte Count / Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2018 Type: Article Affiliation country: United States

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