A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.

Schneider, Christoph; O'Leary, Claire E; von Moltke, Jakob; Liang, Hong-Erh; Ang, Qi Yan; Turnbaugh, Peter J; Radhakrishnan, Sridhar; Pellizzon, Michael; Ma, Averil; Locksley, Richard M

Schneider, Christoph; O'Leary, Claire E; von Moltke, Jakob; Liang, Hong-Erh; Ang, Qi Yan; Turnbaugh, Peter J; Radhakrishnan, Sridhar; Pellizzon, Michael; Ma, Averil; Locksley, Richard M.

Affiliation

Schneider C; Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
O'Leary CE; Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
von Moltke J; Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Liang HE; Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Ang QY; Department of Microbiology & Immunology, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Turnbaugh PJ; Department of Microbiology & Immunology, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Radhakrishnan S; Research Diets, Inc., New Brunswick, NJ 08901, USA.
Pellizzon M; Research Diets, Inc., New Brunswick, NJ 08901, USA.
Ma A; Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Locksley RM; Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA 94143, USA; Department of Microbiology & Immunology, University of California San Francisco (UCSF), San Francisco, CA 94143, USA; Howard Hughes Medical Institute, UCSF. Electronic address: richard.locksley@u

Cell ; 174(2): 271-284.e14, 2018 07 12.

Article in En | MEDLINE | ID: mdl-29887373

Subject(s)

Intestine, Small/physiology; Tritrichomonas/metabolism; Acetates/metabolism; Animals; Dietary Fiber/metabolism; Energy Metabolism; Epithelial Cells/cytology; Epithelial Cells/metabolism; Epithelial Cells/parasitology; Interleukins/genetics; Interleukins/metabolism; Intestinal Mucosa/cytology; Intestine, Small/microbiology; Intestine, Small/parasitology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbiota; Plasmids/genetics; Plasmids/metabolism; Receptors, G-Protein-Coupled/metabolism; Receptors, Interleukin/metabolism; Receptors, Interleukin-17/genetics; Receptors, Interleukin-17/metabolism; Succinic Acid/metabolism; TRPM Cation Channels/metabolism; Tritrichomonas/growth & development; Tumor Necrosis Factor alpha-Induced Protein 3/genetics; Tumor Necrosis Factor alpha-Induced Protein 3/metabolism

Key words

A20; IL-25; ILC2s; TRPM5; Tritrichomonas; concomitant immunity; helminths; succinate; succinate receptor; tuft cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tritrichomonas / Intestine, Small Limits: Animals Language: En Journal: Cell Year: 2018 Type: Article Affiliation country: United States

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