Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models.

Shaltouki, Atossa; Hsieh, Chung-Han; Kim, Min Joo; Wang, Xinnan

Shaltouki, Atossa; Hsieh, Chung-Han; Kim, Min Joo; Wang, Xinnan.

Affiliation

Shaltouki A; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Hsieh CH; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Kim MJ; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Wang X; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA. xinnanw@stanford.edu.

Acta Neuropathol ; 136(4): 607-620, 2018 10.

Article in En | MEDLINE | ID: mdl-29923074

Subject(s)

Drosophila Proteins/genetics; Mitophagy/genetics; Neurons/pathology; Parkinson Disease/genetics; Parkinson Disease/pathology; alpha-Synuclein/metabolism; rho GTP-Binding Proteins/genetics; Animals; Behavior, Animal; Brain/pathology; Cell Differentiation/genetics; Drosophila melanogaster; Humans; Induced Pluripotent Stem Cells/pathology; Mitochondria/genetics; Mitochondria/metabolism; Movement Disorders/genetics; Movement Disorders/psychology; Mutation/genetics; Nerve Degeneration/genetics; Signal Transduction/genetics; Up-Regulation; alpha-Synuclein/genetics

Key words

Alpha-synuclein; Dopaminergic; Fly; Miro; Mitochondria; Mitophagy; Parkinson; iPSC

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Rho GTP-Binding Proteins / Drosophila Proteins / Alpha-Synuclein / Mitophagy / Neurons Limits: Animals / Humans Language: En Journal: Acta Neuropathol Year: 2018 Type: Article Affiliation country: United States

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