DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease.

Krishnan, Navasona; Felice, Christy; Rivera, Keith; Pappin, Darryl J; Tonks, Nicholas K

Krishnan, Navasona; Felice, Christy; Rivera, Keith; Pappin, Darryl J; Tonks, Nicholas K.

Affiliation

Krishnan N; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Felice C; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Rivera K; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Pappin DJ; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Tonks NK; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

Genes Dev ; 32(13-14): 944-952, 2018 07 01.

Article in En | MEDLINE | ID: mdl-29945887

Subject(s)

Chelating Agents/pharmacology; Copper/metabolism; Hepatolenticular Degeneration/drug therapy; Animals; Brain/drug effects; Brain/pathology; Cell Line; Chelating Agents/therapeutic use; Copper/toxicity; Copper-Transporting ATPases/genetics; Copper-Transporting ATPases/metabolism; Disease Models, Animal; Fibroblasts/drug effects; Hepatolenticular Degeneration/physiopathology; Liver/drug effects; Liver/pathology; Mice

Key words

Wilson's; chelator; copper; toxic milk

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chelating Agents / Copper / Hepatolenticular Degeneration Limits: Animals Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2018 Type: Article Affiliation country: United States

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