Super-resolution Imaging of Amyloid Structures over Extended Times by Using Transient Binding of Single ThioflavinâT Molecules.

Spehar, Kevin; Ding, Tianben; Sun, Yuanzi; Kedia, Niraja; Lu, Jin; Nahass, George R; Lew, Matthew D; Bieschke, Jan

Super-resolution Imaging of Amyloid Structures over Extended Times by Using Transient Binding of Single ThioflavinâT Molecules.

Spehar, Kevin; Ding, Tianben; Sun, Yuanzi; Kedia, Niraja; Lu, Jin; Nahass, George R; Lew, Matthew D; Bieschke, Jan.

Affiliation

Spehar K; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Ding T; Department of Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Sun Y; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Kedia N; Department of Energy, Environmental, and Chemical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Lu J; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Nahass GR; Department of Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Lew MD; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Bieschke J; Department of Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.

Chembiochem ; 19(18): 1944-1948, 2018 09 17.

Article in En | MEDLINE | ID: mdl-29953718

Subject(s)

Amyloid beta-Peptides/analysis; Amyloid/analysis; Benzothiazoles/analysis; Fluorescent Dyes/analysis; Optical Imaging/methods; Protein Aggregation, Pathological/diagnostic imaging; Amyloid/ultrastructure; Amyloid beta-Peptides/ultrastructure; Equipment Design; Humans; Microscopy, Fluorescence/instrumentation; Microscopy, Fluorescence/methods; Optical Imaging/instrumentation; Protein Aggregates; Protein Aggregation, Pathological/pathology

Key words

amyloid beta-peptides; long-term imaging; single-molecule localization microscopy; single-molecule studies

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Peptides / Benzothiazoles / Optical Imaging / Protein Aggregation, Pathological / Fluorescent Dyes / Amyloid Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2018 Type: Article Affiliation country: United States

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