Coronarin D induces apoptotic cell death through the JNK pathway in human hepatocellular carcinoma.

Lin, Hui-Wen; Hsieh, Ming-Ju; Yeh, Chao-Bin; Hsueh, Kuan-Chun; Hsieh, Yi-Hsien; Yang, Shun-Fa

Lin, Hui-Wen; Hsieh, Ming-Ju; Yeh, Chao-Bin; Hsueh, Kuan-Chun; Hsieh, Yi-Hsien; Yang, Shun-Fa.

Affiliation

Lin HW; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Hsieh MJ; Department of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.
Yeh CB; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Hsueh KC; Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan.
Hsieh YH; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Yang SF; Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Environ Toxicol ; 33(9): 946-954, 2018 Sep.

Article in En | MEDLINE | ID: mdl-29968959

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis/drug effects; Carcinoma, Hepatocellular/pathology; Diterpenes/pharmacology; JNK Mitogen-Activated Protein Kinases/metabolism; Liver Neoplasms/pathology; Autophagy/drug effects; Caspase 3/metabolism; Caspase 8/metabolism; Caspase 9/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Humans; MAP Kinase Signaling System; Phosphorylation; Up-Regulation; bcl-X Protein/metabolism

Key words

apoptosis; coronarin D; human hepatocellular carcinoma cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Carcinoma, Hepatocellular / JNK Mitogen-Activated Protein Kinases / Diterpenes / Liver Neoplasms / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Environ Toxicol Journal subject: SAUDE AMBIENTAL / TOXICOLOGIA Year: 2018 Type: Article Affiliation country: Taiwan

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