Ectopic expression of recipient CD47 inhibits mouse macrophage-mediated immune rejection against human stem cell transplants.

Leung, Cherry S; Li, Jiatao; Xu, Feng; Wong, Alan S L; Lui, Kathy O

Leung, Cherry S; Li, Jiatao; Xu, Feng; Wong, Alan S L; Lui, Kathy O.

Affiliation

Leung CS; Department of Chemical Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
Li J; Department of Chemical Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
Xu F; Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
Wong ASL; School of Biomedical Sciences, University of Hong Kong, Hong Kong, China.
Lui KO; School of Biomedical Sciences, University of Hong Kong, Hong Kong, China.

FASEB J ; 33(1): 484-493, 2019 01.

Article in En | MEDLINE | ID: mdl-30004796

Subject(s)

CD47 Antigen/metabolism; Ectopic Gene Expression; Embryonic Stem Cells/cytology; Graft Rejection/prevention & control; Immune Tolerance/immunology; Macrophages/immunology; Stem Cell Transplantation/methods; Animals; CD47 Antigen/genetics; Cells, Cultured; Graft Rejection/immunology; Graft Rejection/metabolism; Graft Survival; Humans; Macrophages/metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Inbred NOD; Mice, SCID; Phagocytosis; Transplantation, Heterologous

Key words

ESCs; endothelial cells; immune tolerance; phagocytosis; xenotransplantation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cell Transplantation / CD47 Antigen / Embryonic Stem Cells / Ectopic Gene Expression / Graft Rejection / Immune Tolerance / Macrophages Limits: Animals / Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2019 Type: Article Affiliation country: China

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