Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells.
BMC Complement Altern Med
; 18(1): 218, 2018 Jul 18.
Article
in En
| MEDLINE
| ID: mdl-30021579
ABSTRACT
BACKGROUND:
The polysaccharide component of Angelica gigas induces immuno-stimulatory effects on innate immune cells. However, it is unclear whether A. gigas' adjuvant activity on the immune system can elicit anti-cancer responses.METHODS:
A water-soluble immuno-stimulatory component of A. gigas was prepared. How this ISAg modulated the activation of innate immune cells such as dendritic cells (DCs) was examined. ISAg-induced cytotoxic activity via natural killer (NK) and NKT cells was also tested using a tumor-bearing mouse model.RESULTS:
ISAg treatment induced nitric oxide (NO) production and cytokine gene expression involved in innate immune responses. ISAg activated macrophages and DCs to secrete cytokine IL-12, through the TLR4 signaling pathway. IL-12 plays a crucial role in ISAg-mediated NK and NKT cell activation. Thus, the anti-cancer activity of NK and NKT cells induced ISAg-mediated cytotoxicity of B16 melanoma cells in mice.CONCLUSIONS:
These results indicated that the natural ingredient, ISAg, has adjuvant activity to induce strong anti-cancer activity of NK and NKT cells in vivo.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Extracts
/
Killer Cells, Natural
/
Angelica
/
Natural Killer T-Cells
/
Immunity, Innate
/
Antineoplastic Agents
Limits:
Animals
Language:
En
Journal:
BMC Complement Altern Med
Journal subject:
TERAPIAS COMPLEMENTARES
Year:
2018
Type:
Article
Affiliation country:
South Korea