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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.
Chen, Gang; Huang, Alexander C; Zhang, Wei; Zhang, Gao; Wu, Min; Xu, Wei; Yu, Zili; Yang, Jiegang; Wang, Beike; Sun, Honghong; Xia, Houfu; Man, Qiwen; Zhong, Wenqun; Antelo, Leonardo F; Wu, Bin; Xiong, Xuepeng; Liu, Xiaoming; Guan, Lei; Li, Ting; Liu, Shujing; Yang, Ruifeng; Lu, Youtao; Dong, Liyun; McGettigan, Suzanne; Somasundaram, Rajasekharan; Radhakrishnan, Ravi; Mills, Gordon; Lu, Yiling; Kim, Junhyong; Chen, Youhai H; Dong, Haidong; Zhao, Yifang; Karakousis, Giorgos C; Mitchell, Tara C; Schuchter, Lynn M; Herlyn, Meenhard; Wherry, E John; Xu, Xiaowei; Guo, Wei.
Affiliation
  • Chen G; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Huang AC; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Zhang W; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Zhang G; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Wu M; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
  • Xu W; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Yu Z; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Yang J; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Wang B; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Sun H; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Xia H; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Man Q; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Zhong W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Antelo LF; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Wu B; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Xiong X; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Liu X; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Guan L; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Li T; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Liu S; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Yang R; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Lu Y; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Dong L; Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science, Xi'an Jiaotong University, Xi'an, China.
  • McGettigan S; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Somasundaram R; Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science, Xi'an Jiaotong University, Xi'an, China.
  • Radhakrishnan R; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Mills G; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Lu Y; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Kim J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Chen YH; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Dong H; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
  • Zhao Y; Department of Bioengineering, School of Engineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Karakousis GC; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Mitchell TC; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Schuchter LM; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Herlyn M; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Wherry EJ; Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN, USA.
  • Xu X; Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Guo W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nature ; 560(7718): 382-386, 2018 08.
Article in En | MEDLINE | ID: mdl-30089911
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Escape / Exosomes / B7-H1 Antigen / Programmed Cell Death 1 Receptor / Immune Tolerance / Melanoma Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Escape / Exosomes / B7-H1 Antigen / Programmed Cell Death 1 Receptor / Immune Tolerance / Melanoma Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2018 Type: Article Affiliation country: United States