WBP2 Downregulation Inhibits Proliferation by Blocking YAP Transcription and the EGFR/PI3K/Akt Signaling Pathway in Triple Negative Breast Cancer.

Song, Hongming; Wu, Tianqi; Xie, Dan; Li, Dengfeng; Hua, Kaiyao; Hu, Jiashu; Fang, Lin

Song, Hongming; Wu, Tianqi; Xie, Dan; Li, Dengfeng; Hua, Kaiyao; Hu, Jiashu; Fang, Lin.

Cell Physiol Biochem ; 48(5): 1968-1982, 2018.

Article in En | MEDLINE | ID: mdl-30092563

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Cell Proliferation; Nuclear Proteins/metabolism; Signal Transduction; Transcription Factors/metabolism; Triple Negative Breast Neoplasms/pathology; Animals; Antagomirs/metabolism; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Down-Regulation; ErbB Receptors/metabolism; Female; Humans; Mice; Mice, Nude; MicroRNAs/antagonists & inhibitors; MicroRNAs/genetics; MicroRNAs/metabolism; Nuclear Proteins/genetics; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; RNA Interference; RNA, Small Interfering/metabolism; Trans-Activators; Transcription Factors/genetics; Triple Negative Breast Neoplasms/metabolism

Key words

Apoptosis; MiR-613; Proliferation; Triple Negative Breast Cancer (TNBC); Ww domain-binding protein 2 (WBP2)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Signal Transduction / Adaptor Proteins, Signal Transducing / Cell Proliferation / Triple Negative Breast Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cell Physiol Biochem Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2018 Type: Article

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