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Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.
Spangler, Jamie B; Trotta, Eleonora; Tomala, Jakub; Peck, Ariana; Young, Tracy A; Savvides, Christina S; Silveria, Stephanie; Votavova, Petra; Salafsky, Joshua; Pande, Vijay S; Kovar, Marek; Bluestone, Jeffrey A; Garcia, K Christopher.
Affiliation
  • Spangler JB; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305.
  • Trotta E; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
  • Tomala J; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
  • Peck A; Diabetes Center, University of California San Francisco, San Francisco, CA 94143.
  • Young TA; Laboratory of Tumor Immunology, Institute of Microbiology of the Academy of Sciences of the Czech Republic, 14220 Prague 4-Krc, Czech Republic.
  • Savvides CS; Department of Biochemistry, Stanford University, Stanford, CA 94305.
  • Silveria S; Biodesy, Inc., South San Francisco, CA 94010.
  • Votavova P; Department of Biology, Stanford University, Stanford, CA 94305.
  • Salafsky J; Diabetes Center, University of California San Francisco, San Francisco, CA 94143.
  • Pande VS; Laboratory of Tumor Immunology, Institute of Microbiology of the Academy of Sciences of the Czech Republic, 14220 Prague 4-Krc, Czech Republic.
  • Kovar M; Biodesy, Inc., South San Francisco, CA 94010.
  • Bluestone JA; Department of Bioengineering, Stanford University, Stanford, CA 94305; and.
  • Garcia KC; Laboratory of Tumor Immunology, Institute of Microbiology of the Academy of Sciences of the Czech Republic, 14220 Prague 4-Krc, Czech Republic.
J Immunol ; 201(7): 2094-2106, 2018 10 01.
Article in En | MEDLINE | ID: mdl-30104245
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Recombinant Fusion Proteins / Receptors, Interleukin-2 / Cytokines / T-Lymphocytes, Regulatory / Colitis / Immunotherapy / Antibodies Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2018 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Recombinant Fusion Proteins / Receptors, Interleukin-2 / Cytokines / T-Lymphocytes, Regulatory / Colitis / Immunotherapy / Antibodies Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2018 Type: Article