Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.

Yang, Xinglin; Chen, Xiang-Jun; Yang, Zimo; Xi, Yi-Bo; Wang, Liguo; Wu, Yue; Yan, Yong-Bin; Rao, Yu

Yang, Xinglin; Chen, Xiang-Jun; Yang, Zimo; Xi, Yi-Bo; Wang, Liguo; Wu, Yue; Yan, Yong-Bin; Rao, Yu.

Affiliation

Chen XJ; Eye Center of the Second Affiliated Hospital, Institutes of Translational Medicine , Zhejiang University School of Medicine , Hangzhou 310058 , PR China.

J Med Chem ; 61(19): 8693-8706, 2018 10 11.

Article in En | MEDLINE | ID: mdl-30153006

Subject(s)

Cataract/drug therapy; Crystallins/administration & dosage; Lanosterol/chemistry; Lanosterol/pharmacology; Mutant Proteins/adverse effects; Mutation; Protein Aggregation, Pathological/prevention & control; Cell Survival; Cells, Cultured; Crystallins/chemistry; HeLa Cells; Humans; Lens, Crystalline/cytology; Lens, Crystalline/drug effects; Mutant Proteins/chemistry; Protein Aggregation, Pathological/etiology; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cataract / Crystallins / Mutant Proteins / Protein Aggregation, Pathological / Lanosterol / Mutation Type of study: Etiology_studies / Evaluation_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Type: Article

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