CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (<i>Nrip1</i>) in adipose cells to enhance energy expenditure.

Shen, Yuefei; Cohen, Jessica L; Nicoloro, Sarah M; Kelly, Mark; Yenilmez, Batuhan; Henriques, Felipe; Tsagkaraki, Emmanouela; Edwards, Yvonne J K; Hu, Xiaodi; Friedline, Randall H; Kim, Jason K; Czech, Michael P

CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure.

Shen, Yuefei; Cohen, Jessica L; Nicoloro, Sarah M; Kelly, Mark; Yenilmez, Batuhan; Henriques, Felipe; Tsagkaraki, Emmanouela; Edwards, Yvonne J K; Hu, Xiaodi; Friedline, Randall H; Kim, Jason K; Czech, Michael P.

Affiliation

Shen Y; From the Program in Molecular Medicine and.
Cohen JL; From the Program in Molecular Medicine and.
Nicoloro SM; From the Program in Molecular Medicine and.
Kelly M; From the Program in Molecular Medicine and.
Yenilmez B; From the Program in Molecular Medicine and.
Henriques F; From the Program in Molecular Medicine and.
Tsagkaraki E; From the Program in Molecular Medicine and.
Edwards YJK; the Molecular Basis of Human Disease Graduate Program, School of Sciences, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion, Crete 71003, Greece.
Hu X; From the Program in Molecular Medicine and.
Friedline RH; the Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 and.
Kim JK; the Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 and.
Czech MP; From the Program in Molecular Medicine and.

J Biol Chem ; 293(44): 17291-17305, 2018 11 02.

Article in En | MEDLINE | ID: mdl-30190322

Subject(s)

Adipose Tissue, White/metabolism; Energy Metabolism; Gene Targeting/methods; Nuclear Receptor Interacting Protein 1/genetics; Adipocytes/metabolism; Adipose Tissue, White/cytology; Animals; CRISPR-Cas Systems; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; Gene Editing; Genes, Reporter; Humans; Mice, Inbred C57BL; Nuclear Receptor Interacting Protein 1/metabolism; Plasmids/genetics; Plasmids/metabolism; Uncoupling Protein 1/genetics; Uncoupling Protein 1/metabolism

Key words

CRISPR-delivery particle; CRISPR/Cas; adipocyte; browning; drug delivery system; fat tissue; gene deletion; guide RNA; metabolic disease; nanoparticle; ribonuclear protein (RNP); therapeutic strategy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Targeting / Energy Metabolism / Adipose Tissue, White / Nuclear Receptor Interacting Protein 1 Type of study: Evaluation_studies / Health_economic_evaluation Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2018 Type: Article

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