Genetic manipulation of CCN2/CTGF unveils cell-specific ECM-remodeling effects in injured skeletal muscle.

Petrosino, Jennifer M; Leask, Andrew; Accornero, Federica

Petrosino, Jennifer M; Leask, Andrew; Accornero, Federica.

Affiliation

Petrosino JM; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Leask A; Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Accornero F; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.

FASEB J ; 33(2): 2047-2057, 2019 02.

Article in En | MEDLINE | ID: mdl-30216109

Subject(s)

Connective Tissue Growth Factor; Extracellular Matrix; Gene Expression Regulation; Muscle Fibers, Skeletal; Muscular Dystrophy, Animal; Animals; Connective Tissue Growth Factor/biosynthesis; Connective Tissue Growth Factor/genetics; Extracellular Matrix/genetics; Extracellular Matrix/metabolism; Extracellular Matrix/pathology; Fibrosis; Mice; Mice, Knockout; Muscle Fibers, Skeletal/metabolism; Muscle Fibers, Skeletal/pathology; Muscular Dystrophy, Animal/genetics; Muscular Dystrophy, Animal/metabolism; Muscular Dystrophy, Animal/pathology; Sarcoglycans/deficiency

Key words

fibrosis; muscle regeneration; muscular dystrophy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Muscle Fibers, Skeletal / Extracellular Matrix / Connective Tissue Growth Factor / Muscular Dystrophy, Animal Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2019 Type: Article Affiliation country: United States

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