Novel autophagy modulators: Design and synthesis of (+)-epogymnolactam analogues and structure-activity relationship.

Ueda, Kazuki; Okado, Yuji; Shigetomi, Kengo; Ubukata, Makoto

Ueda, Kazuki; Okado, Yuji; Shigetomi, Kengo; Ubukata, Makoto.

Affiliation

Ueda K; Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
Okado Y; Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
Shigetomi K; Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
Ubukata M; Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan. Electronic address: m-ub@for.agr.hokudai.ac.jp.

Bioorg Med Chem ; 26(18): 5159-5168, 2018 10 01.

Article in En | MEDLINE | ID: mdl-30249498

Subject(s)

Autophagy/drug effects; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Drug Design; Agaricales/chemistry; Animals; Apoptosis/drug effects; Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis; Bridged Bicyclo Compounds, Heterocyclic/chemistry; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Mice; Molecular Structure; NIH 3T3 Cells; Stereoisomerism; Structure-Activity Relationship

Key words

Autophagy inducer; Autophagy inhibitor; Epogymnolactam; NIH3T3 cells; Structure activity relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Drug Design / Bridged Bicyclo Compounds, Heterocyclic Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: Japan

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