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Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils.
Noack, Andreas; Gericke, Birthe; von Köckritz-Blickwede, Maren; Menze, Arne; Noack, Sandra; Gerhauser, Ingo; Osten, Felix; Naim, Hassan Y; Löscher, Wolfgang.
Affiliation
  • Noack A; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • Gericke B; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • von Köckritz-Blickwede M; Department of Physiological Chemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • Menze A; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • Noack S; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • Gerhauser I; Department of Trauma Surgery, Hannover Medical School, 30625 Hannover, Germany.
  • Osten F; Department of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • Naim HY; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • Löscher W; Department of Physiological Chemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Proc Natl Acad Sci U S A ; 115(41): E9590-E9599, 2018 10 09.
Article in En | MEDLINE | ID: mdl-30254169
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Blood-Brain Barrier / Xenobiotics / Endothelial Cells / Lysosomes / Neutrophils Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Blood-Brain Barrier / Xenobiotics / Endothelial Cells / Lysosomes / Neutrophils Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article Affiliation country: Germany