SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells.

Han, Xiuxin; Liu, Fengting; Zhang, Chao; Ren, Zhiwu; Li, Lili; Wang, Guowen

Han, Xiuxin; Liu, Fengting; Zhang, Chao; Ren, Zhiwu; Li, Lili; Wang, Guowen.

Affiliation

Han X; Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of Cancer, Tianjin 300060, People's Republic of China.
Liu F; Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of Cancer, Tianjin 300060, People's Republic of China.
Zhang C; Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of Cancer, Tianjin 300060, People's Republic of China.
Ren Z; Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of Cancer, Tianjin 300060, People's Republic of China.
Li L; Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of Cancer, Tianjin 300060, People's Republic of China.
Wang G; Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of Cancer, Tianjin 300060, People's Republic of China.

Biol Chem ; 400(4): 545-553, 2019 03 26.

Article in En | MEDLINE | ID: mdl-30265649

Subject(s)

Antibiotics, Antineoplastic/pharmacology; Doxorubicin/pharmacology; Drug Resistance, Neoplasm/drug effects; Interleukin-6/antagonists & inhibitors; Nuclear Proteins/antagonists & inhibitors; Osteosarcoma/drug therapy; Ubiquitin-Protein Ligases/antagonists & inhibitors; Zinc Finger E-box-Binding Homeobox 1/antagonists & inhibitors; Antibiotics, Antineoplastic/chemistry; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Doxorubicin/chemistry; Drug Screening Assays, Antitumor; Humans; Interleukin-6/metabolism; Nuclear Proteins/metabolism; Osteosarcoma/metabolism; Osteosarcoma/pathology; Structure-Activity Relationship; Tumor Cells, Cultured; Ubiquitin-Protein Ligases/metabolism; Up-Regulation/drug effects; Zinc Finger E-box-Binding Homeobox 1/metabolism

Key words

Dox resistance; IL-6; SIAH1; ZEB1; osteosarcoma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Doxorubicin / Osteosarcoma / Interleukin-6 / Drug Resistance, Neoplasm / Ubiquitin-Protein Ligases / Zinc Finger E-box-Binding Homeobox 1 / Antibiotics, Antineoplastic Limits: Humans Language: En Journal: Biol Chem Journal subject: BIOQUIMICA Year: 2019 Type: Article

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