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Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes.
Guimaraes, Pedro P G; Tan, Mingchee; Tammela, Tuomas; Wu, Katherine; Chung, Amanda; Oberli, Matthias; Wang, Karin; Spektor, Roman; Riley, Rachel S; Viana, Celso T R; Jacks, Tyler; Langer, Robert; Mitchell, Michael J.
Affiliation
  • Guimaraes PPG; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, United States; Department of Chemical Engineering, MIT, Cambridge, MA, United States; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Depar
  • Tan M; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, United States; Department of Chemical Engineering, MIT, Cambridge, MA, United States.
  • Tammela T; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, United States.
  • Wu K; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, United States.
  • Chung A; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, United States; Department of Chemical Engineering, MIT, Cambridge, MA, United States.
  • Oberli M; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, United States; Department of Chemical Engineering, MIT, Cambridge, MA, United States.
  • Wang K; Department of Bioengineering, Temple University, Philadelphia, PA, United States.
  • Spektor R; Graduate Field of Genetics, Genomics and Development, Cornell University, Ithaca, NY, United States.
  • Riley RS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States.
  • Viana CTR; Department of General Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Jacks T; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, United States.
  • Langer R; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, United States; Department of Chemical Engineering, MIT, Cambridge, MA, United States. Electronic address: rlanger@mit.edu.
  • Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: mjmitch@seas.upenn.edu.
J Control Release ; 290: 75-87, 2018 11 28.
Article in En | MEDLINE | ID: mdl-30290244
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Pyridines / Cyclodextrins / Wnt Proteins / Wnt Signaling Pathway / Adenocarcinoma of Lung / Lung Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2018 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Pyridines / Cyclodextrins / Wnt Proteins / Wnt Signaling Pathway / Adenocarcinoma of Lung / Lung Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2018 Type: Article