TGF-ß suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis.

Takami, Mariko; Cunha, Christina; Motohashi, Shinichiro; Nakayama, Toshinori; Iwashima, Makio

TGF-ß suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis.

Takami, Mariko; Cunha, Christina; Motohashi, Shinichiro; Nakayama, Toshinori; Iwashima, Makio.

Affiliation

Takami M; Department of Microbiology and Immunology, Loyola University, Chicago, IL, USA.
Cunha C; Van Kampen Cardio Pulmonary Research Laboratory, Loyola University, Chicago, IL, USA.
Motohashi S; Department of Medical Immunology, Chiba University, Japan.
Nakayama T; Department of Microbiology and Immunology, Loyola University, Chicago, IL, USA.
Iwashima M; Department of Medical Immunology, Chiba University, Japan.

Eur J Immunol ; 48(12): 1938-1943, 2018 12.

Article in En | MEDLINE | ID: mdl-30298904

Subject(s)

Guanine Nucleotide Exchange Factors/metabolism; T-Lymphocytes, Regulatory/immunology; Thymus Gland/immunology; Transforming Growth Factor beta/metabolism; Animals; Apoptosis; CD28 Antigens/metabolism; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Guanine Nucleotide Exchange Factors/genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Receptor Cross-Talk; Receptors, Antigen, T-Cell/metabolism; Signal Transduction; Tumor Suppressor Protein p53/metabolism

Key words

Foxp3; RasGRP1; TCR; TGF-ß; Tregs

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymus Gland / Transforming Growth Factor beta / T-Lymphocytes, Regulatory / Guanine Nucleotide Exchange Factors Limits: Animals Language: En Journal: Eur J Immunol Year: 2018 Type: Article Affiliation country: United States

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