Role of leukotriene B4 12-hydroxydehydrogenase in &#945;-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer.

Tanaka, Kazuhisa; Kanesaka, Yuri; Takami, Mariko; Suzuki, Akane; Hosokawa, Hiroyuki; Onodera, Atsushi; Kamata, Toshiko; Nagato, Kaoru; Nakayama, Toshinori; Yoshino, Ichiro; Motohashi, Shinichiro

Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer.

Tanaka, Kazuhisa; Kanesaka, Yuri; Takami, Mariko; Suzuki, Akane; Hosokawa, Hiroyuki; Onodera, Atsushi; Kamata, Toshiko; Nagato, Kaoru; Nakayama, Toshinori; Yoshino, Ichiro; Motohashi, Shinichiro.

Affiliation

Tanaka K; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan; Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Kanesaka Y; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Takami M; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Suzuki A; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Hosokawa H; Department of Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Onodera A; Department of Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Kamata T; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan; Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Nagato K; Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Nakayama T; Department of Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Yoshino I; Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan.
Motohashi S; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 2608670, Chiba, Japan. Electronic address: motohashi@faculty.chiba-u.jp.

Biochem Biophys Res Commun ; 506(1): 27-32, 2018 11 17.

Article in En | MEDLINE | ID: mdl-30336981

Subject(s)

Alcohol Oxidoreductases/genetics; Carcinoma, Non-Small-Cell Lung/therapy; Dendritic Cells/immunology; Galactosylceramides/pharmacology; Gene Expression Regulation, Neoplastic; Lung Neoplasms/therapy; Alcohol Oxidoreductases/immunology; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/pathology; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/pathology; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/immunology; Carcinoma, Non-Small-Cell Lung/mortality; Dendritic Cells/cytology; Dendritic Cells/drug effects; Dendritic Cells/transplantation; Dinoprostone/immunology; Dinoprostone/metabolism; Granzymes/genetics; Granzymes/immunology; Humans; Immunotherapy/methods; Interferon-gamma/genetics; Interferon-gamma/immunology; K562 Cells; Lung Neoplasms/genetics; Lung Neoplasms/immunology; Lung Neoplasms/mortality; Natural Killer T-Cells/drug effects; Natural Killer T-Cells/immunology; Natural Killer T-Cells/pathology; Perforin/genetics; Perforin/immunology; Primary Cell Culture; RNA, Messenger/genetics; RNA, Messenger/immunology; Signal Transduction; Survival Analysis

Key words

CD4(+) T cell; CD8(+) T cell; Immunotherapy; LTB4DH; PGE(2); iNKT cell

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Gene Expression Regulation, Neoplastic / Carcinoma, Non-Small-Cell Lung / Alcohol Oxidoreductases / Galactosylceramides / Lung Neoplasms Type of study: Prognostic_studies Language: En Journal: Biochem Biophys Res Commun Year: 2018 Type: Article Affiliation country: Japan

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